Psychobiotics are a special class of probiotics that specifically influence the psyche via the gut-brain axis. Unlike traditional probiotics, which primarily support digestion, psychobiotics directly affect neurochemical processes such as the production of serotonin, GABA, or dopamine. They can alleviate anxiety, reduce stress, and even improve depressive symptoms.
Research in the field of psychobiotics has gained significant momentum in recent years. More and more clinical studies demonstrate that certain probiotic strains have a targeted effect on the central nervous system. In 2025, some of these strains will be the focus of particular attention.
How do psychobiotics affect the brain and mood?
The effect of psychobiotics occurs through several mechanisms:
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Production of neurotransmitters (e.g. serotonin, GABA)
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Modulation of the immune system
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Reduction of inflammatory processes in the nervous system
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Influence on the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the stress response
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Improvement of the barrier function of the intestine ("leaky gut") and the blood-brain barrier
The best psychobiotic strains 2025
Here is a current overview of the top psychobiotic strains with their specific properties and clinically proven effects against stress and anxiety:
| bacterial strain | Main effect | Study situation | Special features |
|---|---|---|---|
| Lactobacillus helveticus R0052 + Bifidobacterium longum R0175 | Reduction of anxiety, cortisol levels and depressive symptoms | Very well documented (randomized, double-blind studies) | Synergy effect through combination, available in dietary supplements |
| Lactobacillus rhamnosus JB-1 | Anxiety-relieving, activates GABA receptors in the brain | Animal models, first human studies | Particularly effective for stress-related irritability |
| Bifidobacterium infantis 35624 | Improvement of the HPA axis, reduction of inflammation | Good study situation | Also helpful for irritable bowel syndrome with psychological components |
| Lactobacillus plantarum 299v | Stress reduction, improvement of cognitive performance | Solid database | Present in foods such as fermented vegetables |
| Bifidobacterium breve CCFM1025 | Effective against social anxiety and depressive symptoms | New, promising studies from 2024 | Combination with Omega-3 shows synergistic effects |
Focus: L. helveticus R0052 + B. longum R0175 – The power duo against stress
This combination is currently considered the most well-researched and effective form of psychobiotics for stress and anxiety relief. Several clinical studies have shown that daily intake of these two strains:
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significantly reduces the stress hormone cortisol
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Symptoms of anxiety and depression measurably reduced
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increases subjective stress tolerance
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improves emotional balance
The combination works synergistically: L. helveticus R0052 modulates inflammatory reactions and improves barrier function in the intestine, while B. longum R0175 influences neurochemical processes and strengthens the HPA axis.
In a double-blind, placebo-controlled study with healthy adults suffering from everyday stress, a significant improvement in psychological resilience, sleep quality and general life satisfaction was observed after 30 days.
Application and dosage
Most effective psychobiotics are available in capsule, powder, or functional food form. Daily intake for at least 4 to 8 weeks is important. Products with specific strain identification (e.g., "contains L. helveticus R0052 and B. longum R0175") are preferable.
When buying, pay attention to:
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Declared strains with scientific name
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Adequate dosage (at least 1–10 billion CFU per day)
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As few additives and stabilizers as possible
Conclusion: Psychobiotics are the future of mental health
Research clearly shows that the targeted intake of certain probiotics can have a positive effect on stress, anxiety, and depressive moods. The combination of L. helveticus R0052 and B. longum R0175, in particular, has established itself as the gold standard in 2025.
Psychobiotics offer a promising, low-side-effect complement to traditional therapies. They can not only alleviate symptoms but also address the underlying causes on a physical level. This places the gut back at the center of holistic health strategies.
Whether for prevention, to accompany therapy or to strengthen general well-being: psychobiotics are a game changer for everyone who wants to live a more emotionally stable life in a natural way.
