In addition to the well-known classics such as Lactobacillus rhamnosus GG or Saccharomyces boulardii, there are also less common but scientifically very interesting probiotic strains whose effects on specific health aspects are well documented. Below, we take a closer look at some of these specialized strains.
Lactobacillus paracasei LP-33 and GMNL-133 – Help with allergies
Allergies such as hay fever and allergic rhinitis are increasing worldwide. Studies show that certain probiotics have immunomodulatory properties, meaning they can influence the immune system so that it reacts less strongly to otherwise harmless substances.
The Lactobacillus paracasei LP-33 strain has been studied in several clinical trials and, when taken regularly, demonstrates significant relief of allergic symptoms , particularly in seasonal allergic rhinitis (e.g., pollen allergy). Symptoms such as a runny nose, sneezing, and itchy eyes were significantly reduced in studies compared to the placebo group.
Lactobacillus paracasei GMNL-133 is also a probiotic strain with immunoregulatory potential. Initial studies show that it can promote anti-inflammatory cytokines and attenuate allergic reactions to environmental factors. The use of such strains could therefore represent an interesting alternative or supplement to conventional antihistamine therapy .
Streptococcus salivarius M18 – For a healthy oral flora
While most probiotics target the gut, there are also strains specifically developed for oral health . Streptococcus salivarius M18 is one such strain that occurs naturally in the mouth.
This probiotic microorganism produces bacteriocins , antimicrobial substances that suppress pathogenic germs in the mouth—such as those that cause gum inflammation (gingivitis), tooth decay, or bad breath. Studies show that regular use of S. salivarius M18 :
-
reduces plaque formation,
-
reduces the number of caries-causing streptococci,
-
and brings the oral microbiome into a healthy balance.
Products containing this strain are usually available in the form of lozenges or mouth sprays – this ensures that the bacteria work where they are needed.
Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 – Support for mental health
The so-called gut-brain axis is an exciting field of research. It describes the close connection between the intestinal flora and the central nervous system. Disturbances in the microbiome have been shown to contribute to psychological problems such as anxiety, stress, or depression.
Particularly promising is the combination of Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 , which has demonstrated anti-anxiety and stress-reducing effects in several clinical studies. Participants who took these probiotics over a period of several weeks reported:
-
less psychological stress,
-
improved sleep quality,
-
increased emotional stability,
-
and reduced cortisol secretion (stress hormone).
These two strains can therefore be a valuable support for stress-related complaints or for the general stabilization of emotional well-being – of course in combination with other measures such as diet, exercise and sleep hygiene.
Overview: Specific probiotic strains by health area
| Health sector | Root name | Area of application | Instructions for use |
|---|---|---|---|
| Allergies | Lactobacillus paracasei LP-33 & GMNL-133 | Allergic rhinitis, hay fever, immunomodulation | Take at least 1 month before the start of the pollen season and continue daily for several weeks |
| Oral health | Streptococcus salivarius M18 | Caries prevention, bad breath, gum health | In the form of lozenges, in the evening after brushing your teeth |
| Mental health | Lactobacillus helveticus Rosell®-52 & Bifidobacterium longum Rosell®-175 | Stress reduction, sleep quality, emotional balance | Combination ideal, daily intake for at least 4 weeks recommended |
Conclusion: Probiotics can have a targeted effect – if the right strains are used
The examples mentioned clearly demonstrate that choosing the right strain is crucial. While non-specific products with a "mixed bag of bacteria" often have little effect, targeted, clinically tested strains can offer real added value for health—be it for allergies, oral health, or mental balance.
Once again, the following applies: Only if the quality criteria (correct dosage, stability, gastric acid resistance and clear declaration) are met can these strains actually develop their effect.
